Central Sensitization, Chronic Pain, Nervous System, Pain Science

Pain is like Memory: Dr. Jay Joshi on Central Sensitization

Okay.  I’ve really been looking forward to publishing this post.

Here, we’re revisiting the same great talk by pain physician Dr. Jay Joshi.  In my last post, I outlined what Dr. Joshi says are the four main categories of pain.

Central sensitization is the type that is, unfortunately, the least understood.  And it’s also the type that’s had the biggest impact on my life to date.

What is it?

Central sensitization is a process through which the central nervous system learns to become more sensitive to, or amplify, pain signals.

I struggled with it for years and thought I was crazy, because I had pain that came and went throughout my own body that most of the doctors and physical therapists I saw couldn’t explain.

Central sensitization is a form of memory.

Generally, we think of central sensitization as a sort of a disorder, because of course, it causes so much pain and suffering.

However, as I’ve touched upon in previous posts, central sensitization actually has its roots in some of the same neural mechanisms that allow us to learn new things and store memories.  We “learn” from pain just as we learn from anything else, and our nervous systems can be changed by it.

As Dr. Joshi says:

“Central sensitization is what happens when the brain is exposed to certain experiences or certain memories.  It’s life… it’s being a human.

When you have a certain memory that forms it, becomes part of who you are… it becomes part of your experience.  And your behavior changes as a result of that.

This is not something that happens randomly…  This is something that happens to the neurophysiology of your brain.  It forms memories.  Those circuits get hardwired on your little ‘hard drive’ that’s known as a brain.  The same thing that happens with pain, when you have a chronic pain stimulus.”

The process of central sensitization is not separate from our brain’s other functions– rather, it belongs to them.

I found this happened to me so often, over the years, before I even knew what central sensitization was.

I’d have a painful experience– the first one was when I threw my back out at age 21— and it was like my nervous system was determined not to let me forget about it afterwards.

According to Dr. Joshi, this is exactly how central sensitization occurs, after a painful or traumatic event:

“You have a painful experience, and usually one of the first things that happens is your brain says ‘hey don’t do that again.'”

It’s trying to protect you from doing the same thing that might have caused you to become injured in the first place.

But what happens when that signal doesn’t stop? 

In cases like mine, this process can go on indefinitely.  Your brain keeps trying to protect you, telling you not to repeat certain activities, long past what’s actually necessary or conducive to your well-being.

This is called the wind-up phenomenon— when the brain’s protective mode stays on, and never gets the signal to turn “off” like it should.  Instead, it just keeps repeating the message of “don’t do that again”– even if it’s something that, technically, should be safe for you to do.

Once this process, the pain can sort of build on itself, like a snowball effect.  And you can remain in pain, long after the original injury that might have set all this off as healed.

Does all chronic pain cause central sensitization?

Dr. Joshi explains that chronic pain is likely to lead to some degree of central sensitization.  (This is significantly higher than other estimates I’ve heard, such as Dr. Elliot Krane’s figure of 10%).

However, I think Dr. Joshi’s explanation makes a lot of sense.  After all, when you experience chronic pain, you’re basically bombarding your nervous system with opportunities to practice sending pain signals.  Why wouldn’t it get better at doing so, the same way you can get better at playing the piano or riding a bike?

Central sensitization is still a part of my life.

I don’t expect to ever be able to totally reverse the process that first began, for me, at age 21.

However, I was able to make a lot of positive changes and gain back a lot of control over my body through pain neurophysiology education, which I write about a lot on this blog.  (Basically, it involves teaching your nervous system what it’s like to feel safe again, so that it can turn the “volume” back down on the pain).

There’s a lot more to say!

Dr. Joshi has some great thoughts on how to improve the medical profession’s understanding of central sensitization, as well as ketamine infusions– a potentially powerful treatment for patients with central sensitization.

I’ll be sharing more on this coming up– hope you liked this post!

Central Sensitization, Chronic Pain, Inspiration, Interesting Articles, Nervous System, Pain Science

The Four Categories of Pain– Dr. Jay Joshi

Hi everyone!

I’ve just discovered this awesome talk on central sensitization by pain management physician Dr. Jay Joshi.  It’s totally packed with information I want to share with you all– such as why it’s so hard to get help for central sensitization, and how ketamine infusion treatments can help.  There’s so much here, though, that I thought I’d break it down into bite-sized information for you.

So, to start out, let’s look at what Dr. Joshi says are the four main types of pain.  (For the purposes of this blog post, I’m actually jumping ahead to the 8:50 mark– later, we’ll come back to the beginning).  

The four types:

  1. Nociceptive
  2. Neuropathic
  3. Inflammatory
  4. Central Sensitization

1. Nociceptive pain: pain that results from actual tissue damage, or potential tissue damage (like if you’re starting to bend a joint past its normal range of motion).  It is “the common discomfort we have all experienced as a result of injury — a paper cut, a broken bone, or appendicitis, among other things.

More on nociceptive pain and its subtypes

2. Neuropathic pain: involves physical damage to the nerves or the central nervous system itself.  It can also occur when the person has a tumor that’s pressing upon a nerve.

3. Inflammatory Pain: Pain produced by the chemicals our body releases as part of the inflammatory or healing process.  On a small scale, think of how a bruise swells up and is painful to the touch.  This is because our body is sending special cells and chemical messengers to that part of our body in order to heal it– and also to make it painful, so that we know to protect the area.  This is inflammatory pain, and it can also happen on a much larger scale with more serious injuries.

4. Central Sensitization: And here we are– the type of pain that’s most affected my life.  It has to do with the concept of neuroplasticity: that the central nervous system (the brain and spinal cord) can change in response to the things it experiences.

When your body experiences a painful event or an injury, it learns from that experience, the same way it learns from anything.  Practice makes perfect– when your brain gets enough practice at sending pain signals, it gets better at it gets better at it.  In a way, this is for your protection– you learn and become more sensitive to performing the same kinds of actions or motions that may have caused this injury in the first place.

However, as a protective mechanism, central sensitization can sort of backfire.  Eventually, we can reach a point where our nervous systems are trying to protect us too much, when we’re not really at risk of injury anymore.

So these are the four main types.

Unfortunately for those of us suffering from central sensitization, it’s the type of pain that doctors and other medical professionals know the least about.

As Dr. Joshi explains, “there are physicians who claim to be pain physicians… who are anesthesiologists… who don’t even understand it.  And they’re teaching at major programs.  It’s scary.”

Central sensitization is as real a type of pain as any of the other three.  And, as Dr. Joshi says, if you’re going to be able to adequately treat pain as a doctor, you better be aware of all four categories.

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Dr. Joshi also has some really great analogies which help to explain the phenomenon of central sensitization further.  I’ll be elaborating on some of those in my next post.

I hope this was helpful!

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Also: you may have noticed that I’ve been playing around with my blog’s format.  I’ve honestly never truly been happy with the appearance of my blog, because I find my options are so limited with premade WordPress themes.  I’m beginning to experiment a little (and even spend a little bit extra!) to try to get things right.  If you have any thoughts or suggestions how improve the appearance of my blog, please let me know!

 

 

 

 

 

Central Sensitization, Interesting Articles

Can music block pain signals? Music-induced analgesia

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I, personally, have known for a long time that music could help reduce my pain levels.  It’s just something that I always knew intuitively. Listen to music (good music, of course) –> feel better.

That’s why I was so intrigued when I found the following post from my friend Jo Malby on some of the science behind how music can lessen our experience of pain.  (I’m sharing it here with her permission, of course!).

Jo writes:

“The joy we derive from listening to music we love, much like anything that brings us joy, is always beneficial in helping us cope with chronic illness and pain. According to ongoing studies, researchers have found that there are many reasons for pain patients to listen to music they love.

Outside of the times when pain is too fierce or your body too sensitized and flared-up for sound or vibration, music can be a useful coping tool, though not only for the joy and escape music brings you.

With real physiological changes in the brain, listening to your favourite music can have a significant, positive impact on perception of chronic pain, as well as the pain itself, with some studies even finding music resulted in less intense pain levels.

Music also reduces anxiety and depression, both often natural consequences of unpredictable debilitating chronic illness and pain, and both difficult to manage and treat. Though it’s often under used as an natural anti-depressant.

Research has drawn its theories on how nerve impulses in the central nervous system are affected by music. Anything that distracts us from pain may reduce the extent to which we focus on it; music helps us shift our attention from the pain but it’s also emotionally engaging, especially if the piece has memories or associations.

With even the rarest of tunes now online — from YouTube to Spotify to Soundcloud to more exclusive sites — search for some of your favourite sounds or create playlists with songs that specifically help you through particularly difficult times or when pain is especially severe, and you need to calm it and your state of mind.

Personally, nothing gives my mood a lift like a little Billy Holiday, Dusty Springfield or Aretha; if feeling frustrated, Chavela Vegas (anger’s better in Spanish). More recently, Mozart’s been on repeat. I love music. (Almost) every genre. Find what you love. Play it. See if it helps you cope, lifts your mood, or offers a momentary sonic escape from the complexities that come with pain and chronic illness.

Scientists now know that listening to music involves a huge portion of the brain — auditory areas, of course, but also motor (movement) areas, the limbic system (involved in emotions), and areas of the brain believed to be responsible for increased creative thought.

Anything that lights up areas in the brain other than pain may also be helpful to reduce that pain.  ((Sidenote from Christy: this reminds me of some of the really cool resources I’ve linked to from Neil Pearson!)).

These effects may not be powerful enough in isolation but added to your pain management toolkit, using music when you are feeling frustrated or sad, depressed or angry, lost or alone, all can help you cope, feel better emotionally, and even lessen a tiny bit of pain.

A study conducted by Peter Vuust, of the Center for Functionally Integrative Neuroscience (CFIN) at Aarhus University, Denmark, found that fibromyalgia patients experienced less chronic pain after listening to their favourite music.

Additionally, recent studies on music therapy and chronic pain conditions found that music reduces anxiety, depression and pain— just from listening to music.

The effect is often referred to as ‘music-induced analgesia‘, and though that analgesia may be more subtle than profound, anything that helps you must be embraced.”

Some additional links:

Science Nordic: Music can relieve chronic pain

The Conversation: How music can relieve chronic pain

BBC News: How music can reduce chronic pain

Prevention.com: More music, less pain?

Study: Emotional valence contributes to music-induced analgesia

Body in Mind: Music modulation of pain perception

And for more from Jo:

Jo Malby is an amazing writer living with and sharing her experience of complex regional pain syndrome (CRPS) on her site The Princess in the Tower.

She also runs the site Inspire Portal, where she shares resources to provide creative inspiration to writers (and other artists!).

Definitely check out more of what she has to say!

Pain Science

Pain Neurotags– Human AntiGravity Suit

A pain neurotag has to do with our brains’ representations of pain.  Individual people process pain differently, and many different factors affect how our brains process and store memories of painful events.

I thought this was a great post from Human AntiGravity Suit on how two professional athletes might experience and store memories of injuries differently.  The injury that appears more “serious” to the outside world might not be the injury that is the more devastating in the long run.

Chronic Pain, Fibromyalgia

Someday there could be a test for fibromyalgia

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One of the reasons I am so optimistic about the future is that someday I believe we will have a way for doctors to see just how much pain a person is in.  It won’t be a matter of taking the patient’s word for it (though that should be enough) or wondering whether or not a patient is faking it.  Instead, there will objective results right on the screen.

What I am talking about is functional magnetic resonance imaging, or fMRI.  An fMRI is slightly different from what most people think of as an MRI.

A regular MRI takes “snapshots” of what is going on in the body.  Your doctor might send you for an MRI of your spine if you are suffering from back pain.  Sometimes women have breast MRI’s if something odd shows up on a mammogram.  An MRI shows you what is happening in the body at a particular moment in time.

An fMRI, on the other hand, is a way of looking at blood flow in the brain.  It shows which parts of the brain are more active than others.  Because the more active parts of the brain require more oxygen, an fMRI will show increased blood flow to those areas.

Researchers working with fMRI have been able to identify distinct patterns of brain activity in the brains of chronic pain sufferers.  These patterns of activity set chronic pain sufferers apart from normal, healthy individuals.  These distinct patterns are unique to people with chronic pain and are sometimes referred to as a “pain phenotype.”

I have heard of several research groups in the US who are investigating whether or not pain sufferers can learn to “rewire” their brains using the information given in an fMRI.  This is done by using a form of biofeedback.   There is evidence to suggest this can be done.   (If you would like to know more about biofeedback, check out these great explanations by Christopher DeCharms and Dr. Sean Mackey).

I’ll be writing more on the idea of biofeedback in a later post.  For now, the fact that an fMRI can even show pain activity is exciting to me.  In a world where chronic pain/fibromyalgia patients are routinely pushed aside, dismissed, and belittled, fMRI offers us all hope.

People who really understand pain know that it can be a disease in its own right.   Once a person’s nervous system gets wound-up enough (yes, “wind-up” is actually one of the scientific terms that refers to this process), the pain can be out of control, and no longer in proportion to whatever physical injury might have originated it.

With brain imaging, this phenomenon will become more clear.  Perhaps someday, pictures of the “pain phenotype” will  appear in everyone’s medical school textbooks.  A sympathetic doctor won’t be something we have to travel far and wide for, like the pot of gold at the end of the rainbow.  Pain will be understood as a disease in its own right, and perhaps then adequate pain medication can actually be given.

Or… who knows.  Maybe pain patients won’t need as much medication because instead, we will be able to learn to control the pain-processing parts of our brains using biofeedback.

Either way, I am optimistic!

For more information, you can check out a new page in my Resources section called “Brain Imaging for Chronic Pain.”

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**Ok, so this photo is actually a picture of someone’s heart, but it looks a lot like the fMRI’s I’ve seen in documentaries.  I know there are better pictures out there, but I get nervous about that whole copyright infringement thing, so for now I’m sticking to what I can find in Creative Commons.  Thank you to Glyn Nelson.**

Above rainbow picture courtesy of SugarBear1956 on Flickr

Chronic Pain, Favorites, Fibromyalgia, Pain Science

Understanding pain as an overprotective friend

grand canyon

Let’s say you’re sightseeing at the Grand Canyon.  You are with a trusted friend enjoying a scenic overlook when notice your friend is walking a little bit too close to the edge of the cliff.

“Hey, watch out!” you say.  You can see that no one else is standing that close to the edge.  Your friend keeps going.

“Hey!” you shout.  “I think you’re too close!”  Your friend still keeps going.

You start to panic.  Your pulse races.  You’re starting to get a picture, in your mind, of what it would look if your friend actually fell over the edge.  “OH MY GOD WHAT ARE YOU DOING?” you scream at the top of your lungs.

This is a metaphor that my favorite pain researcher Neil Pearson uses to explain how pain works.  Pain is like a friend that’s trying to protect you, and if you ignore it, it will get louder.

grand canyon 2

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As I touched upon in a previous post, pain isn’t always an indicator that something is wrong in your body.   Sometimes, your nervous system causes you to feel pain as a warning.  For example, maybe you are performing some kind of motion or exercise that is going to hurt you—pain will prevent you from stretching a muscle or a joint past its normal range.  You feel pain before you have pushed the stretch too far and actually strained anything.

To come to terms with chronic pain, you must first understand that pain doesn’t necessarily mean that a part of your body is injured.  Instead, it means that your body is warning you about something, or that it wants you to change your course of action.

A lot of the pain scientists I cite on this blog offer anecdotes about how pain is not always correlated with a person’s level of injury.  This is important to understand, because it can help people with chronic pain and fibromyalgia not to fear the pain so much.  I find these stories fascinating, so I will be passing them on as much as I can without feeling like maybe I’m relying too much on someone else’s work (it’s hard, because I honestly just want everyone to know what these guys say!)

But it’s also important to understand that all these stories about how pain doesn’t mean you are necessarily injured do not mean you should ignore pain.  That is what I absolutely love about Neil Pearson’s approach.  Even though he is all about teaching people not to fear pain so much, he still says that you have to respect it.

grand canyon 3

Pain is like that overprotective friend.  Pain occurs when your nervous system has decided that something you are doing is dangerous.  This is true whether an injury has already occurred (for example, you sprained your ankle and now your body is telling you to get the heck off of it!) or whether your body thinks an injury might occur (for example, you’re pushing a stretch too far).

Regardless of whether or not a physical injury has already occurred, if you try to ignore pain and keep doing what you are doing, it will get louder.   When you’re doing something that your body thinks is dangerous, your nervous system becomes that friend screaming at you to stop getting so close to the edge of the Grand Canyon.  The more you keep going, the louder your nervous system gets because it’s panicking—the same way you would if you saw a beloved friend too close to the edge.

Of course, this doesn’t mean you have to be crippled by your pain, either.  There are basically two ends of the extreme in dealing with pain: one end is to try to be tough and completely ignore it, and the other end is to be terrified of it and let it dictate what you do and don’t do.

When I was a runner in high school, I was far too influenced by the people around me who placed an emphasis on “no pain, no gain.”  (There were a lot of things wrong with the running culture at my high school—a subject for another day).  The mindset that it was good to block out pain and keep going eventually led me to develop compartment syndrome, the injury that ended my running career, and left me unable to walk or stand up for prolonged amounts of time until I had surgery a few years later.

After developing this injury, I of course went all the way to the opposite end of the spectrum.  I blamed myself for not listening to my body, and felt as though my injury could have been preventable.  I freaked out every time something hurt, an approach that also ended up being counterproductive.  I mean, it’s good to be careful, but now that I understand that I have issues with central sensitization, I realize that not every pain is worth freaking out over.

There is instead a middle way, where you learn to respect your body’s pain without automatically assuming you are injured.  This means you respect the pain and don’t try to push through it, but you also know not to freak out because you recognize that your nervous system sometimes gives you false alarms.  It’s about being okay with the possibility that maybe you strained something and need to take it easy, while knowing that you probably didn’t.

I will be talking more about other techniques to work with your nervous system in the future, but this metaphor is really the cornerstone to understanding pain. For more information, check out Neil Pearson and his amazing online lectures that I am always trying to get people to watch!

Photo Credits (all from Flickr):

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Central Sensitization, Chronic Pain, Favorites, Fibromyalgia, Interesting Articles, Pain Science

Amazing TED Talk: The Mystery of Pain as a Disease

I can’t believe I haven’t seen this video until now.  It was incredibly validating, and I absolutely loved it.

http://www.ted.com/talks/elliot_krane_the_mystery_of_chronic_pain.html

It is given by Elliot Krane, who is a pediatrician and anesthesiologist at Stanford University.  He discusses a lot of the changes that take place in the nervous system of a person with chronic pain in a way that makes total sense.

Favorite quote:

Chronic pain is “…a positive feedback loop…. It’s almost as if somebody came into your home and rewired yours walls so that the next time you turned on the light switch, the toilet flushed three doors down, or your dishwasher went on, or your computer monitor turned off.  It sounds crazy, but that’s what happens with chronic pain.”

Definitely a must-watch!

Central Sensitization, Chronic Pain, Favorites, Pain Science

The Nervous System and Chronic Pain

Sometimes, pain can persist even after the original injury or disease that caused it has healed.

There are several different factors that can cause this.  The one that’s played the largest role in my own life involves the concept of neuroplasticity— the idea that the nervous system can change over time, and that in chronic pain sufferers, it can actually become more sensitive to pain.

In this post I”ll be sharing what I’ve learned about neuroplasticity, as well as some of the other potential causes for chronic, persistent pain.

Neuroplasticity, or Practice Makes Perfect

They say practice makes perfect— in scientific terms, this is known as neuroplasticity, or the idea that the nervous system can be molded and changed by different experiences.  The more chances you give your nervous system to perform a task, the better it becomes at it.  In most cases this is a good thing—neuroplasticity allows you to learn how to walk, how to ride a bike, how to play the piano.  This ability of our nervous systems to learn new information and adapt to different life circumstances has been a fundamental part of our evolutionary history.

But sometimes this tendency of our nervous systems to become better at things with practice is a bad thing.  If you give your nervous system enough “practice” experiencing pain, it will become better and better at it.  The pathways between your nerves and your brain involved in sensing pain will become more and more developed.  It’s as though you’ve turned up the volume dial in your head, and now you hear everything, even the quiet parts, at an incredibly high volume.  For some people, even a tap on the shoulder or the feeling of clothing on their skin can be excruciating.

There are a few scientific terms to describe this phenomenon, but the one that seems to be the most widely used is central sensitization.

Central sensitization

“Central” refers to the central nervous system (the brain and spinal cord) and “sensitization” means, well, the process of becoming more sensitive.

People who go through an extremely painful physical experience may find later that they suffer from central sensitization.  It could be a car accident, a severe injury, or even surgery.  Anything that is traumatic to the body can begin this snowball effect in which the constant pain signals traveling through your nervous system cause it to be more and more sensitive to them.  The exact reasons why it happens to one person versus another are not known.

I developed my chronic pain disorder a few months after my surgery for compartment syndrome in 2004.  It’s possible that the surgery itself triggered the changes in my nervous system– as one physical therapist explained it to me, being cut open is very traumatic for the body, whether or not you are awake to experience it. The other possibility is that it was triggered when I threw my back out a few months later.  That was the point at which the chronic pain began and never really left me.  I’ll never really know for sure which it was, because many people have told me that it can take some time for a chronic pain problem to manifest itself even after the precipitating event.  In all likelihood, it was a combination of the two things.

Pain Alarm System

Neil Pearson and other pain scientists describe pain as the body’s “alarm system.” This alarm system allows your body to communicate with you either that physical damage to your tissues has already occurred, or that physical damage might occur.  Pain is a protective mechanism; it alerts you when you need to take action, or to stop doing something that could damage your body.

In people with chronic pain, the pain alarm system has gone into overdrive, and it has begun to warn you about things that, in reality, do not really pose a danger to your body.  Of course, you have no way of knowing that– the changes to your nervous system occur completely outside of your conscious control, and all of the pain you feel is real.  Just because sometimes pain does not correspond to actual physical injury does not mean it feels any different to the brain.  All pain is 100% real, whether it stems from any sort of damage to your body, or from sensitization of the nervous system.  This is when you end up like me, going to the doctor’s office all the time only to be told they have no idea what’s wrong with you.

I find a lot of comfort in remembering that pain is an alarm system.  Our bodies developed the ability to experience pain not to torture us (though it definitely feels like it sometimes) but to help protect us.  Pain is what tells you to take your hand off of a hot burner, and not to walk on a broken leg.  It’s what tells you not to take that stretch so far that you tear any muscle fibers, and not to try to lift that heavy weight again.

Neil Pearson likens an overactive pain alarm system to an overprotective friend: your friend is worried about you, and really wants you to stop doing whatever he or she thinks you’re doing that is so dangerous.  His advice on how to deal with this “overprotective friend” has helped me more than anything else on this chronic pain journey.

Myofascial Pain Syndrome

Here is where things get a bit complicated.  Although myofascial pain syndrome and central sensitization syndrome are technically not the same thing, I am not convinced it’s fair to think of them as completely separate disorders. I have symptoms of both, as I think most chronic pain sufferers do.

I generally defer to the Mayo Clinic website when I want a definitive answer on such matters.  According to them, “In myofascial pain syndrome, pressure on sensitive points in your muscles (trigger points) causes pain in seemingly unrelated parts of your body. This is called referred pain.”

A diagnosis of myofascial pain syndrome is generally based on whether or not the patient has these painful trigger points.  The Mayo Clinic says that this condition “…typically occurs after a muscle has been contracted repetitively. This can be caused by repetitive motions used in jobs or hobbies or by stress-related muscle tension.”

I don’t know about you, but to me that last part about muscle knots forming due to “stress-related muscle tension” starts to sound similar to what someone who has gone through central sensitization would experience.  At least, it does when you consider that one of the theories for the cause of trigger points is that that they form near a nerve that is constantly freaking out due to chronic pain.  The idea is that when you have pain signals flooding your nervous system day in and day out, your body reacts as though its been damaged.  Your muscles spasm up as a protective mechanism, to keep you from using the “damaged” part of your body until it heals.  This is why I find it hard to view myofascial pain syndrome as entirely separate from the idea of central sensitization.

Other Potential Factors in Chronic Pain:

Sleep Deprivation

Studies have shown that when you take generally healthy people and deprive them of sleep, they begin to exhibit the same symptoms reported by people with fibromyalgia (read this and this).  This is not to say that sleep-deprivation has been found to trigger chronic pain all on its own, but its certainly interesting, especially for someone like me who has had life-long difficulty sleeping.  Personally, I think it’s very possible that my perpetual difficulties sleeping contributed to my developing a problem with chronic pain.

Depression

Numerous studies have demonstrated a relationship between depression and chronic pain.  I’m sure I will surprise no one when I say that chronic pain patients have been shown to suffer from depression at higher rates than the general population.

On the flip side, depression has been shown to cause physical symptoms such as back pain or headache.

What came first– the pain or the depression?– can seem like somewhat of a chicken vs. the egg question.  If you suspect depression might be playing a role in your pain, I would definitely seek professional help and investigate further.

However, I personally had the opposite experience, where I came to feel that many of the doctors I saw were too quick to attribute my pain to depression, even though I insisted repeatedly, and with absolute certainty, that I wasn’t depressed.  If you are being treated by someone who gives you the impression that they think your pain is being caused entirely by depression, and you disagree, I would definitely look for a second opinion.

Anti-depressants have been shown to help with chronic pain, but that doesn’t necessarily mean the pain was caused by depression.  It does mean that depression and chronic pain are likely to share similar physical pathways in the brain, however.  Studies have demonstrated that much lower doses of anti-depressants have been found to be helpful for chronic pain than are normally needed for depression.

Maybe Your Doctors Have Missed Something

Yes: in my book, this counts as an official cause of chronic pain.  If your doctor doesn’t understand why you are in pain, he or she will probably tell you that you have an increased sensitivity to pain.  This is not always a safe assumption.  People don’t always undergo central sensitization after an injury (I certainly had my share of running injuries in high school, but up until I developed compartment syndrome, I always recovered from these and was eventually pain-free).

Doctors miss things all the time.  Perhaps you have scar tissue in your knee that’s getting in the way from an old injury or surgery.   Perhaps one of your legs is almost imperceptibly longer than the other and you need orthotics and a lift in one shoe.  Don’t let a diagnosis of chronic pain make you stop looking for other answers.  You may indeed have a problem with central sensitization, but you might find there are very real orthopedic interventions you can make to cut down on your level of pain.  At the very least, don’t give up looking for other answers before you have an X-ray or MRI of the afflicted part of your body.