Scientific Articles

I’ll be adding to this as time goes on!  For now:

The Prevalence of Fibromyalgia in Other Chronic Pain Conditions, by Muhammad Yunus.  Great article that discusses how conditions such as fibromyalgia syndrome, irritable bowel syndrome, temporomandibular disorder, restless legs syndrome, and chronic fatigue syndrome share a common link in central sensitization.  (Yunus calls them central sensitivity syndromes).

History of fibromyalgia past to present (Muhammad Yunus).

Fibromyalgia and overlapping disorders: the unifying concept of central sensitivity syndromes (Yunus).

Central sensitivity syndromes: a new paradigm and group nosology for fibromyalgia and overlapping conditions, and the related issue of disease versus illness. (Yunus).

Central Sensitization: Uncovering the Relationship Between Pain and Plasticity.  Clifford Woolf, Anesthesiology, 2007.

Central sensitization: Implications for the diagnosis and treatment of pain.  Clifford Woolf; published in Pain, March 2011.

Biology & Therapy of Fibromyalgia: Pain in Fibromyalgia Syndrome, by Ronald Staud.  From the Arthritis Research and Therapy Journal, courtesy of the National Institutes of Health.

New and emerging therapeutic agents for the treatment of fibromyalgia: an update by Jill M. Recla.  From the Journal of Pain Research

Fitzcharles, M.-A., & Yunus, M. B. (2012). The Clinical Concept of Fibromyalgia as a Changing Paradigm in the Past 20 Years. Pain Research and Treatment, 2012, 184835.

A Randomized Controlled Trial of Intensive Neurophysiology Education in Chronic Low Back Pain: a scholarly article that discusses how Lorimer Moseley and his team found that teaching patients about pain can increase their level of function (providing evidence in support of pain neurophysiology education).

Latremoliere, A., & Woolf, C. J. (2009). Central Sensitization: A Generator of Pain Hypersensitivity by Central Neural Plasticity. The Journal of Pain : Official Journal of the American Pain Society, 10(9), 895–926.

Von Hehn, C. A., Baron, R., & Woolf, C. J. (2012). Deconstructing the Neuropathic Pain Phenotype to Reveal Neural Mechanisms. Neuron, 73(4), 638-652.

Central Sensitization and other Medical Conditions:

Managing Chronic Tinnitus as a Phantom Auditory Pain

Reynolds, W. S., Dmochowski, R., Wein, A., & Bruehl, S. (2016). Does central sensitization help explain idiopathic overactive bladder? Nature Reviews. Urology, 13(8), 481–491.

Examining the Specific Mechanisms of Central Sensitization

The role of peptides in central sensitization

The contribution of GABAA and glycine receptors to central sensitization: disinhibition and touch-evoked allodynia in the spinal cord.

Baron, R. (2009).  Neuropathic Pain: a clinical perspective.  Handb Exp Pharmacol, 194, 3-30. doi: 10.1007/978-3-540-79090-7_1.
  • “If a precise clinical phenotypic characterization of the neuropathic pain is combined with a selection of drugs that act on those mechanisms, it should ultimately be possible to design optimal treatments for individuals.”